A few months ago a few colleagues asked me if I could turn a design document into a low-fi clickable prototype to demonstrate interaction design on an application we were developing. I also talked to an IA recently who had the same need to demonstrate interaction, but lamented over the tools at our disposal.
I've used Visio and Axure Pro in the past to do quick and dirty demos of interaction. With Visio, it's been easy to link sheets together. But I've been spending my time primarily in OmniGraffle Pro lately, so I wanted to demonstrate to the other Mac-using IA's and IxD's out there how you can do the same thing.
With this simple process you can create working prototypes with exported PDFs or HTML with clickable images/image maps. The next step to get this to be a richer tool would be to have working form fields in the prototype, but not sure yet how you would do that natively. The hack would be to absolutely position divs for form elements over the OG image.